Project-relevant Publications

2024

Bykov YS, Zuttion S, Senger B, Klein O, Asraf Y, Meyer H, Becker HD, Kucharczyk R, Schuldiner M (2024) A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes. bioRxiv. [Preprint] https://doi.org/10.1101/2024.04.17.589881.

Charmpilas N, Sotiriou A, Axarlis K, Tavernarakis N, Hoppe T (2024) Reproductive regulation of the mitochondrial stress response in Caenorhabditis elegans. Cell Rep. 43(6):114336.

Hees JT, Segura I, Schneider A, Schifferer M, Misgeld T, Harbauer AB (2024) ER-associated biogenesis of Pink1 preprotein for neuronal mitophagy. bioRxiv. [Preprint] https://doi.org/10.1101/2024.06.21.600039.

Hees JT, Wanderoy S, Lindner J, Helms M, Murali Mahadevan H, Harbauer AB (2024) Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons. Nat Metab. 6(3):514-530.

Jackson J, Hoffmann C, Scifo E, Wang H, Wischhof L, Piazzesi A, Mondal M, Shields H, Zhou X, Mondin M, Ryan EB, Döring H, Prehn JHM, Rottner K, Giannone G, Nicotera P, Ehninger D, Milovanovic D, Bano D (2024) Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology. Cell Death Dis. 15(4):304.

Koch C, Lenhard S, Räschle M, Prescianotto-Baschong C, Spang A, Herrmann JM (2024) The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria. EMBO Rep. 25(4):2071-2096.

Minoia M, Quintana-Cordero J, Jetzinger K, Kotan IE, Turnbull KJ, Ciccarelli M, Masser AE, Liebers D, Gouarin E, Czech M, Hauryliuk V, Bukau B, Kramer G, Andréasson C (2024) Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis. Nat Commun. 15(1):1382.

Mogk A, den Brave F (2024) Fine-tuning stress responses by auxiliary feedback loops that sense damage repair. J Cell Biol. 223(12): e202410205.

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P (2024) Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Mol Cell. 84(2):345-358.e5.

Ruger-Herreros C, Svoboda L, Mogk A, Bukau B (2024) Role of j-domain proteins in yeast physiology and protein quality control. J Mol Biol. 436(14):168484.

Renz C, Asimaki E, Meister C, Albanèse V, Petriukov K, Krapoth NC, Wegmann S, Wollscheid HP, Wong RP, Fulzele A, Chen JX, Léon S, Ulrich HD (2024) Ubiquiton-An inducible, linkage-specific polyubiquitylation tool. Mol Cell. 84(2):386-400.e11.

2023

Adamoski D, Dias MM, Quesñay JEN, Yang Z, Zagoriy I, Steyer AM, Rodrigues CT, da Silva Bastos AC, da Silva BN, Costa RKE, de Abreu FMO, Islam Z, Cassago A, van Heel MG, Consonni SR, Mattei S, Mahamid J, Portugal RV, Ambrosio ALB, Dias SMG (2023) Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection. Nat Struct Mol Biol. 30(12):1902-1912.

Anton V, Buntenbroich I, Simões T, Joaquim M, Müller L, Buettner R, Odenthal M, Hoppe T, Escobar-Henriques M (2023) E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response. Mol Cell. 83(16):2976-2990.e9.

Boll V, Hermanns T, Uthoff M, Erven I, Hörner EM, Kozjak-Pavlovic V, Baumann U, Hofmann K (2023) Functional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis. Nat Commun. 14(1):7335.

Bueno D, Narayan Dey P, Schacht T, Wolf C, Wüllner V, Morpurgo E, Rojas-Charry L, Sessinghaus L, Leukel P, Sommer C, Radyushkin K, Florin L, Baumgart J, Stamm P, Daiber A, Horta G, Nardi L, Vasic V, Schmeisser MJ, Hellwig A, Oskamp A, Bauer A, Anand R, Reichert AS, Ritz S, Nocera G, Jacob C, Peper J, Silies M, Frauenknecht KBM, Schäfer MKE, Methner A (2023) NECAB2 is an endosomal protein important for striatal function. Free Radic Biol Med. 208:643-656.

Buntenbroich I, Anton V, Perez-Hernandez D, Simões T, Gaedke F, Schauss A, Dittmar G, Riemer J, Escobar-Henriques M (2023) Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target. iScience. 26(7):107014.

Ebstein F, Küry S, Most V, Rosenfelt C, Scott-Boyer MP, van Woerden GM, Besnard T, Papendorf JJ, Studencka-Turski M, Wang T, Hsieh TC, Golnik R, Baldridge D, Forster C, de Konink C, Teurlings SMW, Vignard V, van Jaarsveld RH, Ades L, Cogné B, Mignot C, Deb W, Jongmans MCJ, Cole FS, van den Boogaard MH, Wambach JA, Wegner DJ, Yang S, Hannig V, Brault JA, Zadeh N, Bennetts B, Keren B, Gélineau AC, Powis Z, Towne M, Bachman K, Seeley A, Beck AE, Morrison J, Westman R, Averill K, Brunet T, Haasters J, Carter MT, Osmond M, Wheeler PG, Forzano F, Mohammed S, Trakadis Y, Accogli A, Harrison R, Guo Y, Hakonarson H, Rondeau S, Baujat G, Barcia G, Feichtinger RG, Mayr JA, Preisel M, Laumonnier F, Kallinich T, Knaus A, Isidor B, Krawitz P, Völker U, Hammer E, Droit A, Eichler EE, Elgersma Y, Hildebrand PW, Bolduc F, Krüger E, Bézieau S (2023) PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production. Sci Transl Med. 15(698):eabo3189.

Fromm SA, O'Connor KM, Purdy M, Bhatt PR, Loughran G, Atkins JF, Jomaa A, Mattei S (2023) The translating bacterial ribosome at 1.55 Å resolution generated by cryo-EM imaging services. Nat Commun. 14(1):1095.

Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakamura K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF (2023) NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nat Commun. 14(1):8368.

Gamerdinger M, Jia M, Schloemer R, Rabl L, Jaskolowski M, Khakzar KM, Ulusoy Z, Wallisch A, Jomaa A, Hunaeus G, Scaiola A, Diederichs K, Ban N, Deuerling E (2023) NAC controls cotranslational N-terminal methionine excision in eukaryotes. Science. 380(6651):1238-1243.

Gemin O, Gluc M, Purdy M, Rosa H, Niemann M, Peskova Y, Mattei S, Jomaa A (2023) Hibernating ribosomes tether to mitochondria as an adaptive response to cellular stress during glucose depletion. bioRxiv. [Preprint]https://doi.org/10.1101/2023.10.08.561365.

Gerber M, Suppanz I, Oeljeklaus S, Niemann M, Käser S, Warscheid B, Schneider A, Dewar CE (2023) A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of T. brucei. Life Sci Alliance. 6(11):e202302004.

Giroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Blüher M, Nielsen S, Zeigerer A, García-Cáceres C, Scheideler M, Herzig S, Bartelt A (2023) The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes. EMBO Rep. 24(10):e57600.

Groh C, Haberkant P, Stein F, Filbeck S, Pfeffer S, Savitski MM, Boos F, Herrmann JM (2023) Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins. Life Sci Alliance. 6(6):e202201805.

Günnigmann M, Koubek J, Kramer G, Bukau B (2023) Selective ribosome profiling as a tool to study interactions of translating ribosomes in mammalian cells. Methods Enzymol. 684:1-38.

Hermanns T, Hofmann K (2023) Bioinformatical approaches to the discovery and classification of novel deubiquitinases. Methods Mol Biol. 2591:135-149.

Javitt A, Shmueli MD, Kramer MP, Kolodziejczyk AA, Cohen IJ, Radomir L, Sheban D, Kamer I, Litchfield K, Bab-Dinitz E, Zadok O, Neiens V, Ulman A, Wolf-Levy H, Eisenberg-Lerner A, Kacen A, Alon M, Rêgo AT, Stacher-Priehse E, Lindner M, Koch I, Bar J, Swanton C, Samuels Y, Levin Y, da Fonseca PCA, Elinav E, Friedman N, Meiners S, Merbl Y (2023) The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC. Nat Cancer. 4(5):629-647.

Kim M, Serwa RA, Samluk L, Suppanz I, Kodroń A, Stępkowski TM, Elancheliyan P, Tsegaye B, Oeljeklaus S, Wasilewski M, Warscheid B, Chacinska A (2023) Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction. Nat Commun. 14(1):4092.

Koçberber Z, Willemsen N, Bartelt A (2023) The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function. Front Endocrinol (Lausanne). 14:1176733.

Körner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A (2023) The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. Elife. 12:e92409.

Lenhard S, Gerlich S, Khan A, Rödl S, Bökenkamp JE, Peker E, Zarges C, Faust J, Storchova Z, Räschle M, Riemer J, Herrmann JM (2023) The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis. J Cell Biol. 222(10):e202303002.

Panagiotidou E, Gioran A, Bano D, Chondrogianni N (2023) Neuron-specific proteasome activation exerts cell non-autonomous protection against amyloid-beta (Aβ) proteotoxicity in Caenorhabditis elegans. Redox Biol. 65:102817.

Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, Trifunovic A, Langer T, Gehring NH, Becker T, Riemer J (2023) A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. J Cell Biol. 222(7):e202210019.

Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS (2023) The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nat Commun. 14(1):560.

Schulte U, den Brave F, Haupt A, Gupta A, Song J, Müller CS, Engelke J, Mishra S, Mårtensson C, Ellenrieder L, Priesnitz C, Straub SP, Doan KN, Kulawiak B, Bildl W, Rampelt H, Wiedemann N, Pfanner N, Fakler B, Becker T (2023) Mitochondrial complexome reveals quality control pathways of protein import. Nature. 614:153-159.

Song J, Steidle L, Steymans I, Singh J, Sanner A, Böttinger L, Winter D, Becker T (2023) The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase. Nat Commun. 14:39.

Sutandy FXR, Gößner I, Tascher G, Münch C (2023) A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature. 618(7966):849-854.

Waad Sadiq Z, Brioli A, Al-Abdulla R, Çetin G, Schütt J, Murua Escobar H, Krüger E, Ebstein F (2023) Immunogenic cell death triggered by impaired deubiquitination in multiple myeloma relies on dysregulated type I interferon signaling. Front Immunol. 14:982720.

Wang X, Zhang H, Wang Y, Bramasole L, Guo K, Mourtada F, Meul T, Hu Q, Viteri V, Kammerl I, Konigshoff M, Lehmann M, Magg T, Hauck F, Fernandez IE, Meiners S (2023) DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T-cell immunity. EMBO J. 42(8):e110597.

2022

Ayala Mariscal SM, Pigazzini ML, Richter Y, Özel M, Grothaus IL, Protze J, Ziege K, Kulke M, ElBediwi M, Vermaas JV, Colombi Ciacchi L, Köppen S, Liu F, Kirstein J (2022) Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT. Nat Commun. 13:4692.

Borgert L, Mishra S, den Brave F (2022) Quality control of cytoplasmic proteins inside the nucleus. Comput Struct Biotechnol J. 20:4618-4625.

Bykov YS, Flohr T, Boos F, Zung N, Herrmann JM, Schuldiner M (2022) Widespread use of unconventional targeting signals in mitochondrial ribosome proteins. EMBO J. 41(1):e109519.

Cerullo F, Filbeck S, Patil PR, Hung HC, Xu H, Vornberger J, Hofer FW, Schmitt J, Kramer G, Bukau B, Hofmann K, Pfeffer S, Joazeiro CAP (2022) Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue. Nature. 603(7901):509-514.

Çetin G, Studencka-Turski M, Venz S, Schormann E, Junker H, Hammer E, Völker U, Ebstein F, Krüger E (2022) Immunoproteasomes control activation of innate immune signaling and microglial function. Front Immunol. 13:982786.

Dahan N, Bykov YS, Boydston EA, Fadel A, Gazi Z, Hochberg-Laufer H, Martenson J, Denic V, Shav-Tal Y, Weissman JS, Aviram N, Zalckvar E, Schuldiner M (2022) Peroxisome function relies on organelle-associated mRNA translation. Sci Adv. 8(2):eabk2141.

Dewar CE, Oeljeklaus S, Mani J, Mühlhäuser WWD, von Känel C, Zimmermann J, Ochsenreiter T, Warscheid B, Schneider A (2022) Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes. Nat Commun. 13(1):3084.

Drwesh L, Heim B, Graf M, Kehr L, Hansen-Palmus L, Franz-Wachtel M, Macek B, Kalbacher H, Buchner J, Rapaport D (2022) A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins. Elife. 11:e77706.

Dudanova I (2022) Biosensors for studying neuronal proteostasis. Front Mol Neurosci. 15:829365.

Eismann L, Fijalkowski I, Galmozzi CV, Koubek J, Tippmann F, Van Damme P, Kramer G (2022) Selective ribosome profiling reveals a role for SecB in the co-translational inner membrane protein biogenesis. Cell Rep. 41(10):111776.

Erven I, Abraham E, Hermanns T, Baumann U, Hofmann K (2022) A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins. Nat Commun. 13(1):7643.

Fessler E, Krumwiede L, Jae LT (2022) DELE1 tracks perturbed protein import and processing in human mitochondria. Nat Commun. 13(1):1853.

Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL (2022) Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron. 110(9):1516-1531.e9.

Hermanns T, Pichlo C, Baumann U, Hofmann K (2022) A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun. 13(1):401.

Hermeling JC, Herholz M, Baumann L, Cores EC, Zečić A, Hoppe T, Riemer J, Trifunovic A (2022) Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans. Redox Biol. 58:102533.

Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, Gentile D, Siddig S, Stork M, Hopkins CE, Händler K, Weis J, Roos A, Schultze JL, Nicotera P, Ehninger D, Bano D (2022) SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Mol Metab. 61:101503.

Jawed A, Ho CT, Grousl T, Shrivastava A, Ruppert T, Bukau B, Mogk A (2022) Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis. Front Mol Biosci. 9:1106477.

Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E (2022) Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science. 375(6583):839-844.

Klann K, Münch C (2022) PBLMM: Peptide-based linear mixed models for differential expression analysis of shotgun proteomics data. J Cell Biochem. 123(3):691-696.

Li X, Straub J, Medeiros TC, Mehra , den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF (2022) Mitochondria shed their outer membrane in response to infection-induced stress. Science. 375(6577):eabi4343.

Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Münch C (2022) Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Nat Commun. 13(1):5164.

Piazzesi A, Wang Y, Jackson J, Wischhof L, Zeisler-Diehl V, Scifo E, Oganezova I, Hoffmann T, Gómez Martín P, Bertan F, Wrobel CJJ, Schroeder FC, Ehninger D, Händler K, Schultze JL, Schreiber L, van Echten-Deckert G, Nicotera P, Bano D (2022) CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. EMBO Rep. 23(5):e52606.

Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C (2022) Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Mol Cell. 82(2):435-446.e7.

Shrivastava A, Sandhof CA, Reinle K, Jawed A, Ruger-Herreros C, Schwarz D, Creamer D, Nussbaum-Krammer C, Mogk A, Bukau B (2022) The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved. J Cell Biol. 221(10):e202202149.

Priesnitz C, Böttinger L, Zufall N, Gebert M, Guiard B, van der Laan M, Becker T (2022) Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation. Cell Rep. 39:1108619.

Ravanelli S, Li Q, Annibal A, Trifunovic A, Antebi A, Hoppe T (2022) Reprograming of proteasomal degradation by branched chain amino acid metabolism. Aging Cell. 21(12):e13725.

Wegmann S, Meister C, Renz C, Yakoub G, Wollscheid HP, Takahashi DT, Mikicic I, Beli P, Ulrich HD (2022) Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass. Mol Cell. 82(8):1589-1602.e5.

Willemsen N, Arigoni I, Studencka-Turski M, Krüger E, Bartelt A (2022) Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3. Mol Metab. 62:101518.

Wischhof L, Lee HM, Tutas J, Overkott C, Tedt E, Stork M, Peitz M, Brüstle O, Ulas T, Händler K, Schultze JL, Ehninger D, Nicotera P, Salomoni P, Bano D (2022) BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. EMBO J. 41(23):e110595.

Wischhof L, Scifo E, Ehninger D, Bano D (2022) AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases. EBioMedicine. 83:104231.

Wolf C, Pouya A, Bitar S, Pfeiffer A, Bueno D, Rojas-Charry L, Arndt S, Gomez-Zepeda D, Tenzer S, Bello FD, Vianello C, Ritz S, Schwirz J, Dobrindt K, Peitz M, Hanschmann EM, Mencke P, Boussaad I, Silies M, Brüstle O, Giacomello M, Krüger R, Methner A (2022) GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton. Commun Biol. 5(1):541.

Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, Tatzelt J, Cali T, Winklhofer KF (2022) LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. EMBO J. 41(24):e112006.

Zhang L, Dietsche F, Seitaj B, Rojas-Charry L, Latchman N, Tomar D, Wüst RC, Nickel A, Frauenknecht KB, Schoser B, Schumann S, Schmeisser MJ, Vom Berg J, Buch T, Finger S, Wenzel P, Maack C, Elrod JW, Parys JB, Bultynck G, Methner A (2022) TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy. Life Sci Alliance. 5(10):e202201478.

Zhou J, Jung M, Dimmer KS, Rapaport D (2022) The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14. J Cell Biol. 2022 Apr 4;221(4):e202112030.

2021

Backes S, Bykov YS, Flohr T, Räschle M, Zhou J, Lenhard S, Krämer L, Mühlhaus T, Bibi C, Jann C, Smith JD, Steinmetz LM, Rapaport D, Storchová Z, Schuldiner M, Boos F, Herrmann JM (2021) The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress. Cell Rep. 35(1):108936.

Bano D, Salomoni P, Ehninger D, Nicotera P (2021) The histone code in dementia: Transcriptional and chromatin plasticity fades away. Curr Opin Pharmacol. 60:117-122.

Bertan F, Wischhof L, Scifo E, Guranda M, Jackson J, Marsal-Cots A, Piazzesi A, Stork M, Peitz M, Prehn JHM, Ehninger D, Nicotera P, Bano D (2021) Comparative analysis of CI- and CIV-containing respiratory supercomplexes at single-cell resolution. Cell Rep Methods. 1(1):100002.

Bertolini M, Fenzl K, Kats I, Wruck F, Tippmann F, Schmitt J, Auburger JJ, Tans S, Bukau B, Kramer G (2021) Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly. Science. 371(6524):57-64.

Blumenstock S, Schulz-Trieglaff EK, Voelkl K, Bolender AL, Lapios P, Lindner J, Hipp MS, Hartl FU, Klein R, Dudanova I (2021) Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. EMBO J. 40(19):e107260.

Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P (2021) Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. Elife. 10:e68213.

Filbeck S, Cerullo F, Paternoga H, Tsaprailis G, Joazeiro CAP, Pfeffer S (2021) Mimicry of canonical translation elongation underlies alanine tail synthesis in RQC. Mol Cell. 81(1):104-114.e6.

Gallrein C, Iburg M, Michelberger T, Koçak A, Puchkov D, Liu F, Ayala Mariscal SM, Nayak T, Kaminski Schierle GS, Kirstein J (2021) Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity. Prog Neurobiol. 198:101907.

Lee JH, Jomaa A, Chung S, Hwang Fu YH, Qian R, Sun X, Hsieh HH, Chandrasekar S, Bi X, Mattei S, Boehringer D, Weiss S, Ban N, Shan SO (2021) Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. Sci Adv. 7(21):eabg0942.

Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B (2021) Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell Metab. 33(12):2464-2483.e18.

Pigazzini ML, Lawrenz M, Margineanu A, Kaminski Schierle GS, Kirstein J (2021) An expanded polyproline domain maintains mutant huntingtin soluble in vivo and during aging. Front Mol Neurosci. 14:721749.

Poveda-Huertes D, Taskin AA, Dhaouadi I, Myketin L, Marada A, Habernig L, Büttner S, Vögtle FN (2021) Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR. PLoS Genet. 17(7):e1009664.

Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I (2021) Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life Sci Alliance. 5(3):e202101185.

Scheiblich H, Dansokho C, Mercan D, Schmidt SV, Bousset L, Wischhof L, Eikens F, Odainic A, Spitzer J, Griep A, Schwartz S, Bano D, Latz E, Melki R, Heneka MT (2021) Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. Cell. 184(20):5089-5106.e21.

Schlagowski AM, Knöringer K, Morlot S, Sánchez Vicente A, Flohr T, Krämer L, Boos F, Khalid N, Ahmed S, Schramm J, Murschall LM, Haberkant P, Stein F, Riemer J, Westermann B, Braun RJ, Winklhofer KF, Charvin G, Herrmann JM (2021) Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol. EMBO J. 40(16):e107913.

Song J, Herrmann JM, Becker T (2021) Quality control of the mitochondrial proteome. Nat Rev Mol Cell Biol. 22:54-70.

Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C (2021) Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat Commun. 12(1):4284.

Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU (2021) The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nat Commun. 12(1):4863.

Zila V, Margiotta E, Turoňová B, Müller TG, Zimmerli CE, Mattei S, Allegretti M, Börner K, Rada J, Müller B, Lusic M, Kräusslich HG, Beck M (2021) Cone-shaped HIV-1 capsids are transported through intact nuclear pores. Cell. 184(4):1032-1046.e18.

2020

Bie AS, Cömert C, Körner R, Corydon TJ, Palmfeldt J, Hipp MS, Hartl FU, Bross P (2020) An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space. Cell Stress Chaperones. 25(3):407-416.

Bykov YS, Rapaport D, Herrmann JM, Schuldiner M (2020) Cytosolic events in the biogenesis of mitochondrial proteins. Trends Biochem Sci. 45(8):650-667.

den Brave F, Cairo LV, Jagadeesan C, Ruger-Herreros C, Mogk A, Bukau B, Jentsch S (2020) Chaperone-mediated protein disaggregation triggers proteolytic clearance of intra-nuclear protein inclusions. Cell Rep. 31:107680.

Escobar-Henriques M, Altin S, Brave FD (2020) Interplay between the ubiquitin proteasome system and mitochondria for protein homeostasis. Curr Issues Mol Biol. 35:35-58.

Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT (2020) A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol. Nature. 579(7799):433-437.

Finger Y, Habich M, Gerlich S, Urbanczyk S, van de Logt E, Koch J, Schu L, Lapacz KJ, Ali M, Petrungaro C, Salscheider SL, Pichlo C, Baumann U, Mielenz D, Dengjel J, Brachvogel B, Hofmann K, Riemer J (2020) Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import. EMBO J. 39(19):e103889.

Joaquim M, Escobar-Henriques M (2020) Role of mitofusins and mitophagy in life or death decisions. Front Cell Dev Biol. 8:572182.

Klann K, Münch C. Instrument logic increases identifications during mutliplexed translatome measurements (2020) Anal Chem. 92(12):8041-8045.

Klann K, Tascher G, Münch C (2020) Functional translatome proteomics reveal converging and dose-dependent regulation by mTORC1 and eIF2α. Mol Cell. 77(4):913-925.e4.

Pigazzini ML, Gallrein C, Iburg M, Kaminski Schierle G, Kirstein J (2020) Characterization of amyloid structures in aging C. elegans using fluorescence lifetime imaging. J Vis Exp. 157:10.3791/61004.

Pigazzini ML, Kirstein J (2020) In vivo quantification of protein turnover in aging C. elegans using photoconvertible dendra2. J Vis Exp. 160:10.3791/61196.

Poveda-Huertes D, Matic S, Marada A, Habernig L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, Vögtle FN (2020) An early mtUPR: redistribution of the nuclear transcription factor Rox1 to mitochondria protects against Intramitochondrial proteotoxic aggregates. Mol Cell. 77(1):180-188.e9.

Ravanelli S, den Brave F, Hoppe T (2020) Mitochondrial quality control governed by ubiquitin. Front Cell Dev Biol. 8:270.

Renz C, Albanèse V, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Léon S, Ulrich HD (2020) Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting. J Cell Sci. 133(10):jcs244566.

Takahashi TS, Wollscheid HP, Lowther J, Ulrich HD (2020) Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA. Nucleic Acids Res. 48(6):3042-3052.

Vitali DG, Drwesh L, Cichocki BA, Kolb A, Rapaport D (2020) The biogenesis of mitochondrial outer membrane proteins show variable dependence on import factors. iScience. 23(1):100779.

2019

Araiso Y, Tsutsumi A, Qiu J, Imai K, Shiota T, Song J, Lindau C, Wenz LS, Sakaue H, Yunoki K, Kawano S, Suzuki J, Wischnevski M, Schütze C, Ariyama H, Ando T, Becker T, Lithgow T, Wiedemann N, Pfanner N, Kikkawa M, Endo T (2019) Structure of the mitochondrial import gate reveals distinct preprotein paths. Nature. 575:395-401.

Becker T, Song J, Pfanner N (2019) Versatility of preprotein transfer from the cytosol to mitochondria. Trends Cell Biol. 29:534-548.

Boos F, Krämer L, Groh C, Jung F, Haberkant P, Stein F, Wollweber F, Gackstatter A, Zöller E, van der Laan M, Savitski MM, Benes V, Herrmann JM (2019) Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme. Nat Cell Biol. 21(4):442-451.

Calabrese G, Peker E, Amponsah PS, Hoehne MN, Riemer T, Mai M, Bienert GP, Deponte M, Morgan B, Riemer J (2019) Hyperoxidation of mitochondrial peroxiredoxin limits H2O2-induced cell death in yeast. EMBO J. 38(18):e101552.

Escobar-Henriques M, Joaquim M (2019) Mitofusins: Disease gatekeepers and hubs in mitochondrial quality control by E3 ligases. Front Physiol. 10:517.

Gamerdinger M, Kobayashi K, Wallisch A, Kreft SG, Sailer C, Schlömer R, Sachs N, Jomaa A, Stengel F, Ban N, Deuerling E (2019) Early scanning of nascent polypeptides inside the ribosomal tunnel by NAC. Mol Cell. 75(5):996-1006.e8.

Galmozzi CV, Merker D, Friedrich UA, Döring K, Kramer G (2019) Selective ribosome profiling to study interactions of translating ribosomes in yeast. Nat Protoc. 14(8):2279-2317.

Gioran A, Piazzesi A, Bertan F, Schroer J, Wischhof L, Nicotera P, Bano D (2019) Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction. EMBO J. 38(6):e99558.

Ho CT, Grousl T, Shatz O, Jawed A, Ruger-Herreros C, Semmelink M, Zahn R, Richter K, Bukau B, Mogk A (2019) Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis. Nat Commun. 10(1):4851.

Mårtensson CU, Priesnitz C, Song J, Ellenrieder L, Doan KN, Boos F, Floerchinger A, Zufall N, Oeljeklaus S, Warscheid B, Becker T (2019) Mitochondrial protein translocation-associated degradation. Nature. 569:679-683.

Meul T, Berschneider K, Schmitt S, Mayr CH, Mattner LF, Schiller HB, Yazgili AS, Wang X, Lukas C, Schlesser C, Prehn C, Adamski J, Graf E, Schwarzmayr T, Perocchi F, Kukat A, Trifunovic A, Kremer L, Prokisch H, Popper B, von Toerne C, Hauck SM, Zischka H, Meiners S (2020) Mitochondrial regulation of the 26S proteasome. Cell Rep. 32(8):108059.

Shen K, Gamerdinger M, Chan R, Gense K, Martin EM, Sachs N, Knight PD, Schlömer R, Calabrese AN, Stewart KL, Leiendecker L, Baghel A, Radford SE, Frydman J, Deuerling E (2019) Dual role of ribosome-binding domain of NAC as a potent suppressor of protein aggregation and aging-related proteinopathies. Mol Cell. 74(4):729-741.e7.

van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF (2019) A protein quality control pathway regulated by linear ubiquitination. EMBO J. 38(9):e100730.