Projects

Dissecting the mechanisms linking proteasome function to mitochondrial proteostasis

The role of J-domain proteins in quality control of mitochondrial protein import

Nuclear quality control of non-imported mitochondrial precursor proteins

The contribution of cytosolic chaperones to the biogenesis of mitochondrial proteins

Mechanisms of mitochondrial proximal translation and co-translational protein import

Regulation of the human proteostasis network under mitochondrial protein import stress

The role of cotranslational protein biogenesis factors in the translation and targeting of mitochondrial precursor proteins

Interplay between local translation of mitochondrial proteins and proteostasis in neurons

MFN2 role, origin and evolution in protein aggregation and mitochondrial import capacity

Causes, consequences and correction of mitochondrial protein misfolding

Early steps in the biogenesis of mitochondrial inner membrane proteins: The role of cytosolic factors in synthesis, targeting and quality control

Coordination of proteostasis and mitochondrial intermembrane space protein import

In vivo profiling of authentic cytosolic targeting routes of mitochondrial precursor proteins

The role of lysosomal protein degradation in mitochondrial membrane stress responses

Contributions of ubiquitin signaling to the maintenance of mitochondrial import channels