SPP2453 “Integration of mitochondria into the cellular proteostasis network”
The Priority Program SPP2453, consisting of 33 research groups from different German research institutions, is funded by the German Research Foundation (DFG) since September 2024. A particular feature of the Priority Program is the nationwide collaboration between its participating researchers. The research consortium aims to investigate how mitochondrial biogenesis and function are embedded into the cellular proteostasis network. For this, joint forces from two different disciplines are used: Experts in mitochondrial protein biogenesis and experts in cellular proteostasis will combine highly innovative techniques to obtain central insights into these fundamental cell biological processes. The findings will contribute to a better understanding of molecular mechanisms underlying aging and the development of neurodegenerative diseases. Read more...
Latest News
Save the Date: International Symposium
The International Symposium of the SPP2453 will take place from May 27-29, 2026 and will feature several top-class speakers.
SPP2453 Summer School 2025
A total of 18 young scientist took part in this year's SPP2453 Summer School on "Protein import into mitochondria".
Latest Publications
OCTOBER 2025: Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration. Nat Cell Biol (2025). Thorsten Hoppe, Project 12 Ι Jan Riemer, Project 12
AUGUST 2025: The mitochondrial unfolded protein response: acting near and far. Biol Chem (2025). Thorsten Hoppe, Project 12
JULY 2025: Interaction with AK2A links AIFM1 to cellular energy metabolism. Mol Cell (2025). Daniele Bano, Project 01 Ι Jan Riemer, Project 12
33
Principal Investigators
38
Young Scientists
15
Scientific Projects
